Description

Carbamic Acid, [(3S,4S)-4-Aminotetrahydro-3-Furanyl]-, 1,1-Dimethylethyl Ester is a high-purity, stereochemically defined chiral intermediate of significant importance in modern pharmaceutical synthesis. Its core value lies in providing a protected, enantiomerically pure amino-tetrahydrofuran scaffold, which is a critical building block for constructing complex active pharmaceutical ingredients (APIs). This compound is essential for research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of novel therapeutics, particularly those targeting central nervous system (CNS) disorders and other specialized treatments.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, particularly those with tetrahydrofuran-based pharmacophores.
• API Development: Serves as a critical building block in the research and process development of new Active Pharmaceutical Ingredients (APIs), especially for neurological and antiviral applications.
• Process Chemistry: Used in scale-up and optimization studies for the commercial manufacturing of pharmaceutical compounds requiring high stereochemical purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the discovery of new chemical entities (NCEs) due to its defined stereochemistry and functional groups.
• Peptidomimetic Synthesis: Acts as a constrained, non-natural amino acid analog for the design and synthesis of peptide-like molecules with enhanced metabolic stability.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) and CDMOs (Contract Development and Manufacturing Organizations) producing specialized intermediates for clients.

Basic Information

Item	Detail
Product Name	Carbamic Acid, [(3S,4S)-4-Aminotetrahydro-3-Furanyl]-, 1,1-Dimethylethyl Ester
CAS No.	335276-55-6
Molecular Formula	C9H18N2O3
Molecular Weight	202.25 g/mol
Synonyms	(3S,4S)-4-[(tert-Butoxycarbonyl)amino]tetrahydrofuran-3-carboxylic acid; tert-Butyl N-[(3S,4S)-4-aminotetrahydrofuran-3-yl]carbamate; Boc-(3S,4S)-4-Amino-tetrahydrofuran-3-yl-amine; (3S,4S)-4-(Boc-amino)tetrahydrofuran-3-carboxylic acid; (3S,4S)-Boc-Amino-tetrahydrofuran; (3S,4S)-4-Amino-tetrahydrofuran-3-carboxylic acid tert-butyl ester; (3S,4S)-4-(tert-Butoxycarbonylamino)tetrahydrofuran-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our Carbamic Acid, [(3S,4S)-4-Aminotetrahydro-3-Furanyl]-, 1,1-Dimethylethyl Ester is produced under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research and development. All products undergo rigorous analytical testing, including chiral HPLC to confirm stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (3S,4S) isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.