Description

Creatine-(Guanidino-13C) Monohydrate is a stable isotope-labeled analog of creatine, where the guanidino carbon is enriched with the 13C isotope. This compound is essential for advanced metabolic and pharmacokinetic research, providing a precise tracer to study creatine synthesis, transport, and utilization in biological systems. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers engaged in stable isotope dilution mass spectrometry (SID-MS) and NMR spectroscopy.

Application

• Biomedical Research Tracer: Used as an internal standard in quantitative mass spectrometry for accurate measurement of endogenous creatine levels in tissues and biofluids.
• Metabolic Pathway Analysis: Enables detailed tracing of the creatine-phosphocreatine circuit in models of muscular, neurological, and cardiac metabolism.
• Drug Development & Pharmacokinetics (PK/PD): Serves as a critical tool in preclinical studies to investigate the bioavailability, distribution, and clearance of novel creatine-based therapeutics.
• Clinical Diagnostics: Facilitates the development of high-precision diagnostic assays for inborn errors of metabolism, such as guanidinoacetate methyltransferase (GAMT) deficiency.
• Nutritional Science Studies: Applied in human and animal studies to precisely track the absorption, tissue retention, and efficacy of supplemental creatine.
• NMR Spectroscopy Reference: Provides a distinct 13C-NMR signal for structural confirmation and dynamic studies of creatine-related biochemical processes.

Basic Information

Product Name	Creatine-(Guanidino-13C) Monohydrate
CAS No.	335081-01-1
Molecular Formula	C4H9N3O2•H2O (with 13C at guanidino position)
Molecular Weight	~152.12 g/mol (13C labeled)
Synonyms	Creatine (guanidino-13C) monohydrate; [Guanidino-13C]Creatine monohydrate; 13C-Creatine monohydrate; (α-Methylguanidino)acetic acid-13C monohydrate; N-Amidinosarcosine-13C monohydrate; N-Carbamimidoyl-N-methylglycine-13C monohydrate; Isotopically labeled creatine; 13C1-Creatine hydrate
EINECS	Contact for details

Quality Control

Our Creatine-(Guanidino-13C) Monohydrate is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (Atom % 13C), chemical purity by HPLC, and specific tests for identity and impurities. We adhere to stringent quality management protocols suitable for research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept sealed in a low-humidity environment to maintain stability and prevent clumping or decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 13C)	≥ 99%
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	10.0% - 13.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.