Description

Desacetyl-N,o-Descarbonyl Linezolid is a key pharmaceutical intermediate and impurity standard used in the synthesis and quality control of the antibiotic linezolid. This high-purity compound is critical for ensuring the safety, efficacy, and regulatory compliance of the final active pharmaceutical ingredient (API). It is primarily utilized by pharmaceutical manufacturers and analytical laboratories engaged in research, development, and production of oxazolidinone-class antibiotics.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of the antibiotic Linezolid.
• Reference Standard: Used as a certified impurity standard in HPLC and LC-MS methods for quality control of Linezolid API and finished drug products.
• Process Development & Validation: Essential for studying and optimizing synthetic pathways, reaction mechanisms, and purification processes.
• Regulatory Compliance & Documentation: Supports the preparation of regulatory filings (e.g., DMF, CMC sections) by providing characterized impurity profiles.
• Analytical Research: Serves as a critical component in method development, stability studies, and degradation pathway analysis for oxazolidinone antibiotics.
• Academic & Contract Research: Used in universities and CROs for pharmacological studies and the development of new antibacterial agents.

Basic Information

Product Name	Desacetyl-N,o-Descarbonyl Linezolid
CAS No.	333753-72-3
Molecular Formula	C15H19FN2O3
Molecular Weight	294.32 g/mol
Synonyms	N-Desacetyl-N,o-didescarbonyl Linezolid; Linezolid Impurity F; Linezolid Related Compound F; (S)-N-[[3-[3-Fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide Desacetyl Descarbamoyl Derivative; UNII-9F5V8U3W0Y; 9F5V8U3W0Y; (S)-N-((3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
EINECS	Contact for details

Quality Control

Our Desacetyl-N,o-Descarbonyl Linezolid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for use as a pharmaceutical reference standard. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.