Description

Boc-(R)-3-Amino-5-Hexynoic Acid CAS NO 332064-91-2 is a high-purity, non-natural amino acid derivative featuring a chiral center and a terminal alkyne functional group. This unique bifunctional structure makes it a critical chiral building block for the synthesis of complex bioactive molecules and novel materials. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced drug discovery, peptide mimetic development, and chemical biology research.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of potential drug candidates, particularly for creating constrained peptide analogs and bioactive compounds.
• Peptidomimetics & Conjugation: The Boc-protected amine and alkyne handle enable efficient solid-phase peptide synthesis (SPPS) and site-specific bioconjugation via click chemistry (e.g., CuAAC).
• Chemical Biology Probes: Used to incorporate alkyne tags into peptides or small molecules for subsequent labeling with azide-functionalized fluorophores or affinity tags (bioorthogonal labeling).
• Material Science: Acts as a monomer or cross-linker precursor for synthesizing specialized polymers with tailored properties via polymerization of the alkyne group.
• Asymmetric Synthesis: Provides a chiral scaffold for constructing more complex, enantiomerically pure molecules in medicinal chemistry campaigns.
• Academic & Industrial R&D: Essential for exploratory research in organic methodology development and for creating targeted libraries for high-throughput screening.

Basic Information

Item	Details
Product Name	Boc-(R)-3-Amino-5-Hexynoic Acid
CAS No.	332064-91-2
Molecular Formula	C11H17NO4
Molecular Weight	227.26 g/mol
Synonyms	(R)-3-((tert-Butoxycarbonyl)amino)hex-5-ynoic acid; (R)-N-Boc-3-amino-5-hexynoic acid; Boc-D-β-Homopropargylglycine; Boc-(R)-3-Amino-5-hexynoate; tert-Butyl (R)-(5-hexyn-3-yl)carbamate; (R)-N-(tert-Butoxycarbonyl)-3-amino-5-hexynoic acid; (3R)-3-[(2-Methylpropan-2-yl)oxycarbonylamino]hex-5-ynoic acid
EINECS	Contact for details

Quality Control

Our Boc-(R)-3-Amino-5-Hexynoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.