Description

Cyclopropanecarbonitrile, 2-(4-Fluorophenyl)-, (1R,2S)- (9Ci) is a high-purity, single-enantiomer chiral building block of significant interest in advanced organic synthesis. This compound matters because its unique cyclopropane and fluorinated aromatic structure provides a rigid, three-dimensional scaffold critical for modulating the biological activity and physicochemical properties of target molecules. It is primarily needed by pharmaceutical and agrochemical R&D organizations for the development of novel active ingredients, particularly where stereochemistry and fluorine substitution are key design elements.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the fluorophenylcyclopropane moiety can enhance metabolic stability and target binding.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Material Science Research: Investigated as a monomer or additive for creating specialized polymers with unique thermal or optical properties.
• Chemical Biology Probes: Utilized in the design of molecular probes to study enzyme mechanisms and protein-ligand interactions due to its stereodefined, rigid structure.

Basic Information

Product Name	Cyclopropanecarbonitrile, 2-(4-Fluorophenyl)-, (1R,2S)- (9Ci)
CAS No.	331941-38-9
Molecular Formula	C10H8FN
Molecular Weight	161.18 g/mol
Synonyms	(1R,2S)-2-(4-Fluorophenyl)cyclopropanecarbonitrile; (1R,2S)-rel-2-(4-Fluorophenyl)cyclopropanecarbonitrile; trans-2-(4-Fluorophenyl)cyclopropanecarbonitrile; 2-(p-Fluorophenyl)cyclopropanecarbonitrile; 2-(4-Fluorophenyl)cyclopropanecarbonitrile (enantiomerically pure); Fluorophenylcyclopropanecarbonitrile; Bicyclo[1.1.0]butane-1-carbonitrile, 3-(4-fluorophenyl)-, (1R,2S)-
EINECS	Contact for details

Quality Control

Our Cyclopropanecarbonitrile, 2-(4-Fluorophenyl)-, (1R,2S)- (9Ci) is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR, and GC/MS for identity and purity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storage under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.