Description

Tau Peptide (307-321) CAS NO 330456-50-3 is a synthetic peptide fragment corresponding to amino acid residues 307-321 of the human microtubule-associated protein tau. This peptide is a critical research tool for studying tau protein biochemistry, aggregation mechanisms, and its role in neurodegenerative pathologies. It is primarily utilized by researchers and developers in the fields of neuroscience, diagnostics, and therapeutic discovery.

Application

• Biomedical Research: Used as a key antigen for the development and validation of antibodies targeting specific epitopes of the tau protein.
• Neurodegenerative Disease Studies: Essential for in vitro studies investigating tau phosphorylation, aggregation into neurofibrillary tangles, and the pathology of Alzheimer's disease and other tauopathies.
• Diagnostic Assay Development: Serves as a critical standard and coating antigen in ELISA, Western blot, and other immunoassay platforms for detecting tau-related biomarkers.
• Drug Discovery Screening: Employed in high-throughput screening assays to identify and evaluate potential therapeutic compounds that inhibit abnormal tau aggregation or interaction.
• Vaccine Research: Investigated as a potential component in active immunization strategies aimed at generating an immune response against pathological tau species.
• Biochemical Characterization: Used in structural biology studies, such as NMR or crystallography, to understand the conformational properties of specific tau domains.

Basic Information

Product Name	Tau Peptide (307-321)
CAS No.	330456-50-3
Molecular Formula	C73H122N22O23S
Molecular Weight	1683.9 g/mol
Synonyms	Tau (307-321) peptide; Tau protein fragment 307-321; Human tau peptide residues 307-321; Microtubule-associated protein tau (307-321); H-THR-GLU-VAL-GLN-ILE-VAL-TYR-LYS-LYS-ASP-VAL-ASP-SER-LYS-OH; Acetylated Tau Peptide (307-321); Biotinylated Tau Peptide (307-321)
EINECS	Contact for details

Quality Control

Our Tau Peptide (307-321) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and MS (Mass Spectrometry) for identity confirmation, to ensure consistency and reliability for critical research applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Water Content (KF)	≤ 8.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.