Description

Tau Peptide (304-318) is a synthetic peptide fragment corresponding to residues 304-318 of the human tau protein. This sequence is of significant interest in neurological research, particularly for studying protein aggregation mechanisms and epitope mapping. It serves as a critical reagent for researchers and pharmaceutical developers focused on neurodegenerative diseases. The compound is supplied as a high-purity material suitable for biochemical assays and immunological studies.

Application

• Neuroscience Research: Used as a key antigen and reference standard in studies investigating tau protein pathology, aggregation, and phosphorylation.
• Antibody Development & Validation: Essential for the production, screening, and characterization of monoclonal and polyclonal antibodies targeting specific tau epitopes.
• Diagnostic Assay Development: Employed in the development and calibration of immunoassays (ELISA, Western Blot) for detecting tau-related biomarkers in biological samples.
• Drug Discovery Platforms: Utilized in high-throughput screening (HTS) and in vitro models to identify and evaluate potential therapeutic compounds that modulate tau interaction or aggregation.
• Biochemical Studies: Serves as a substrate for studying enzyme kinetics, particularly for kinases and phosphatases involved in tau post-translational modification.
• Vaccine Research: Investigated as a potential component in active immunization strategies aimed at targeting pathological tau species in Alzheimer's disease and other tauopathies.

Basic Information

Product Name	Tau Peptide (304-318)
CAS No.	330456-49-0
Molecular Formula	C73H122N22O23S
Molecular Weight	1683.9 g/mol
Synonyms	Tau (304-318) Peptide; Human Tau Protein (304-318); Tau Peptide Fragment 304-318; H-Tyr-Lys-Thr-Ala-Val-Ala-Ile-Thr-Pro-Pro-Lys-Lys-Gly-Glu-Ser-OH; pTau (304-318); PHF-Tau (304-318); Anti-Tau Antibody Epitope Peptide; Neurofibrillary Tangle Tau Peptide
EINECS	Contact for details

Quality Control

Every batch of Tau Peptide (304-318) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment includes adherence to relevant guidelines for research-grade biochemicals. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), molecular weight confirmation (by MS), and peptide content is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70%
Molecular Weight	1683.9 ± 2.0 Da
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or dilute aqueous acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.