Description

Tau Peptide (277-291) CAS NO 330456-40-1 is a synthetic peptide fragment corresponding to amino acid residues 277-291 of the human tau protein. This specific sequence is of significant interest in neurological research, particularly for studying protein aggregation mechanisms and their role in neurodegenerative diseases. It serves as a critical research tool for scientists and pharmaceutical developers in the fields of neuroscience, biochemistry, and drug discovery.

Application

• Neuroscience Research: Used as a key antigen for generating antibodies specific to the tau protein.
• Biochemical Assay Development: Employed in ELISA, Western blot, and other immunoassays to study tau protein expression and pathology.
• Drug Discovery Screening: Serves as a target molecule in high-throughput screening for potential therapeutics targeting tau aggregation in Alzheimer's disease and other tauopathies.
• Mechanistic Studies: Utilized in in vitro studies to investigate the phosphorylation, aggregation, and fibrillization properties of tau protein fragments.
• Diagnostic Tool Development: Acts as a reference standard in the development of diagnostic tests for detecting pathological tau species.

Basic Information

Product Name	Tau Peptide (277-291)
CAS No.	330456-40-1
Molecular Formula	C73H119N21O22
Molecular Weight	1590.87 g/mol
Synonyms	Tau (277-291) Peptide; Tau Protein Fragment (277-291); Human Tau (277-291); H-Tyr-Lys-Val-Glu-Ile-Val-Tyr-Lys-Ser-Val-Val-Gly-Asp-Ser-Lys-OH; VQIVYKPVDLSKVTS; pTau (277-291); Phospho-tau Peptide (277-291) (if applicable)
EINECS	Contact for details

Quality Control

Our Tau Peptide (277-291) is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including HPLC for purity and MS for identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture absorption. For long-term storage, consider storing desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Molecular Weight	1590.87 ± 2 Da (by MS)
Amino Acid Composition	Conforms to theoretical values
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.