Description

Tau Peptide (274-288) is a synthetic peptide fragment corresponding to amino acid residues 274-288 of the human microtubule-associated protein tau. This specific sequence is of significant interest in neuroscience and Alzheimer's disease research, as it falls within key functional domains of the tau protein. It serves as a critical research-grade biochemical tool for studying protein-protein interactions, phosphorylation events, and aggregation mechanisms. Primary users include pharmaceutical R&D teams, academic research institutions, and diagnostic developers focused on neurodegenerative diseases and tauopathies.

Application

• Biochemical Research: Used as a standard or substrate in studies investigating tau protein structure, function, and post-translational modifications.
• Antibody Development & Epitope Mapping: Serves as a key antigen for generating and characterizing monoclonal and polyclonal antibodies specific to the tau protein.
• In Vitro Assay Development: Employed in ELISA, Western blot, and other immunoassays to develop diagnostic and research tools for detecting tau-related biomarkers.
• Neurodegenerative Disease Modeling: Utilized in cell-based and biochemical assays to model tau aggregation and screen potential therapeutic compounds for Alzheimer's disease and other tauopathies.
• Kinase/Phosphatase Substrate Studies: Acts as a substrate to study the activity of kinases (e.g., GSK-3β) and phosphatases that regulate tau phosphorylation at specific sites within this sequence.
• Peptide-Protein Interaction Studies: Applied in pull-down assays, surface plasmon resonance (SPR), or isothermal titration calorimetry (ITC) to map interaction partners of the tau protein.

Basic Information

Product Name	Tau Peptide (274-288)
CAS No.	330456-39-8
Molecular Formula	C73H124N22O23
Molecular Weight	1637.9 g/mol
Synonyms	Tau (274-288) Peptide; Tau Protein Fragment 274-288; hTau (274-288); Microtubule-Associated Protein Tau (274-288); Tau Peptide Sequence 274-288; PHF-Tau Peptide (274-288); Alzheimer's Tau Peptide (274-288); KVQIINKKLDLSNVQ
EINECS	Contact for details

Quality Control

Our Tau Peptide (274-288) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, MS, and amino acid analysis. We adhere to research-grade standards suitable for critical in vitro applications, with the capability to supply custom grades for specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Within ± 10% of theoretical
Peptide Content	≥ 70% (by weight)
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.