Description

Tau Peptide (268-282) CAS NO 330456-37-6 is a synthetic peptide fragment corresponding to residues 268-282 of the human microtubule-associated protein tau. This high-purity peptide is a critical research tool for studying tau protein aggregation, phosphorylation, and its role in neurodegenerative pathologies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers focused on Alzheimer's disease and other tauopathies.

Application

• Biomedical Research: Fundamental studies on tau protein biochemistry, structure, and function.
• Antibody Development & Epitope Mapping: Serves as a key antigen for generating and characterizing tau-specific antibodies.
• Drug Discovery Screening: Used in in vitro assays to screen for compounds that inhibit tau aggregation or modulate its phosphorylation.
• Diagnostic Assay Development: A critical component in the development of ELISA and other immunoassays for detecting tau-related biomarkers.
• Neuroscience Studies: Investigating the molecular mechanisms underlying Alzheimer's disease, frontotemporal dementia, and related disorders.
• Quality Control Reference Standard: Used as a certified reference material (CRM) for calibrating analytical methods in related research and development.

Basic Information

Product Name	Tau Peptide (268-282)
CAS No.	330456-37-6
Molecular Formula	C73H115N21O23S
Molecular Weight	1630.88 g/mol
Synonyms	Tau (268-282) Peptide; Tau Protein Fragment 268-282; Human Tau Peptide (268-282); MAPT (268-282); Microtubule-Associated Protein Tau Peptide (268-282); pS262 Tau Peptide (if phosphorylated variant); VQIINK peptide (common name based on sequence); H-Val-Gln-Ile-Ile-Asn-Lys-OH (single-letter amino acid sequence)
EINECS	Contact for details

Quality Control

Every batch of Tau Peptide (268-282) is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. Our standard quality commitment includes HPLC purity ≥95%, confirmation of amino acid sequence by mass spectrometry (MS), and verification of correct molecular weight. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided with each shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ±10% of theoretical composition
Solvent Residues	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.