Description

2-(4-(Trifluoromethyl)Thiazol-2-Yl)Acetonitrile is a high-value, heterocyclic organic building block featuring a reactive nitrile group and a trifluoromethylated thiazole core. This compound is essential for medicinal chemistry and agrochemical research, enabling the rapid synthesis of novel molecules with enhanced biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and crop protection industries for constructing complex target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group often improves lipophilicity and bioactivity.
• Material Science Research: Serves as a precursor for functionalized polymers or liquid crystals that require specific electronic properties from the thiazole and nitrile functionalities.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and inhibitors for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-(4-(Trifluoromethyl)Thiazol-2-Yl)Acetonitrile
CAS No.	329978-21-4
Molecular Formula	C6H3F3N2S
Molecular Weight	192.16 g/mol
Synonyms	2-(4-(Trifluoromethyl)-1,3-thiazol-2-yl)acetonitrile; 2-[4-(Trifluoromethyl)-1,3-thiazol-2-yl]acetonitrile; Acetonitrile, 2-[4-(trifluoromethyl)-2-thiazolyl]-; 2-(4-Trifluoromethylthiazol-2-yl)acetonitrile; 2-Thiazoleacetonitrile, 4-(trifluoromethyl)-; 4-(Trifluoromethyl)-2-thiazoleacetonitrile; (4-Trifluoromethyl-thiazol-2-yl)-acetonitrile
EINECS	Contact for details

Quality Control

Our 2-(4-(Trifluoromethyl)Thiazol-2-Yl)Acetonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and to support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.