Description

Quetiapine Sulfoxide is a key pharmaceutical intermediate and a major metabolite of the antipsychotic drug Quetiapine. Its precise synthesis and high purity are critical for research into drug metabolism, pharmacokinetic studies, and the development of analytical reference standards. This compound is primarily required by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers engaged in the production or quality control of Quetiapine and related therapeutics.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of Quetiapine and its metabolites in analytical methods.
• Metabolite Research: Essential for in-vitro and in-vivo studies investigating the metabolic pathways, bioavailability, and clearance of Quetiapine.
• Analytical Method Development: Serves as a critical component in developing and validating HPLC, LC-MS, and other chromatographic assays for impurity profiling and bioanalysis.
• Pharmacokinetic Studies: Employed in studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of the parent drug.
• Impurity Standard: Used to qualify and control Quetiapine Sulfoxide as a specified impurity in active pharmaceutical ingredient (API) and finished drug product specifications.
• Chemical Synthesis Intermediate: Acts as a precursor or an intermediate in the synthetic pathways for novel chemical entities or derivative compounds.

Basic Information

Product Name	Quetiapine Sulfoxide
CAS No.	329216-63-9
Molecular Formula	C21H25N3O3S
Molecular Weight	399.51 g/mol
Synonyms	2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol S-Oxide; Quetiapine S-Oxide; Quetiapine Sulfoxide; ICI 204,636 Sulfoxide; Quetiapine Metabolite (Sulfoxide); 11-[4-[2-(2-Hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepine 5-Oxide
EINECS	Contact for details

Quality Control

Our Quetiapine Sulfoxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all test results against predefined specifications is provided with every shipment to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.