Description

3-Chloro-5-Fluorophenylboronic Acid is a high-purity boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl structures.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific halogenated aromatic frameworks.
• Material Science: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where its structure aids in tuning electronic properties.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organoboron catalysts used in asymmetric synthesis.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for constructing complex organic molecules and exploring new synthetic pathways.
• Custom Synthesis: Provides a foundational unit for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	3-Chloro-5-Fluorophenylboronic Acid
CAS No.	328956-61-2
Molecular Formula	C6H5BClFO2
Molecular Weight	173.37 g/mol
Synonyms	(3-Chloro-5-fluorophenyl)boronic acid; 3-Chloro-5-fluorobenzeneboronic acid; B-(3-Chloro-5-fluorophenyl)boronic acid; 3-Chloro-5-fluoro phenylboronic acid; 3-Cl-5-F-C6H3B(OH)2; 328956-61-2; Boronic acid, B-(3-chloro-5-fluorophenyl)-
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Fluorophenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.