Description

3-Fluoro-5-Formylphenylboronic Acid is a versatile and highly functionalized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a formyl and a boronic acid group on a fluorinated aromatic ring, makes it an indispensable reagent for constructing complex molecular architectures. This compound is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in cross-coupling reactions and as a precursor for more elaborate intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) via Suzuki-Miyaura cross-coupling reactions, enabling the formation of biaryl structures common in drug molecules.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atom and formyl group can be leveraged to fine-tune biological activity and stability.
• Ligand and Catalyst Development: Serves as a starting material for creating sophisticated ligands and organocatalysts used in asymmetric synthesis and other catalytic processes.
• Material Science Research: Employed in the construction of organic frameworks, polymers, and liquid crystals, where its functional groups allow for precise molecular engineering and property modulation.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and sensors for studying biological processes, taking advantage of the boronic acid group's affinity for diols.
• Custom Synthesis & Contract Manufacturing: An essential building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	3-Fluoro-5-Formylphenylboronic Acid
CAS No.	328956-60-1
Molecular Formula	C7H6BFO3
Molecular Weight	167.93 g/mol
Synonyms	(3-Fluoro-5-formylphenyl)boronic acid; 5-Borono-3-fluorobenzaldehyde; 3-Fluoro-5-formylbenzeneboronic acid; 3-Fluoro-5-carboxaldehydephenylboronic acid; 3-Fluoro-5-aldehydophenylboronic acid; 3-Fluoro-5-formylphenyl-B(OH)2; 3-Fluoro-5-formylbenzeneboronic acid pinacol ester (protected form)
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-Formylphenylboronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. We employ advanced analytical techniques including HPLC, NMR, and LC-MS for comprehensive characterization and purity verification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the rigorous demands of research and development as well as scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.