Description

Bazedoxifene 4’-β-D-Glucuronide is a major, pharmacologically relevant metabolite of the selective estrogen receptor modulator (SERM) bazedoxifene. This compound is of critical importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics (PK), and bioanalytical method validation. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the development and regulatory submission of bazedoxifene-based therapies.

Application

• Reference Standard for Bioanalysis: Serves as a critical certified reference material (CRM) for the quantification of bazedoxifene and its metabolites in biological matrices (plasma, serum, urine) using LC-MS/MS or HPLC methods.
• Metabolite Identification & Profiling: Used in in vitro and in vivo ADME (Absorption, Distribution, Metabolism, Excretion) studies to identify and characterize the metabolic pathways of bazedoxifene.
• Pharmacokinetic (PK) Studies: Essential for determining the pharmacokinetic profile, including clearance rates and exposure levels, of the glucuronidated metabolite in preclinical and clinical research.
• Drug Impurity Testing: Acts as a specified impurity standard in the quality control of bazedoxifene active pharmaceutical ingredient (API) and finished drug products to ensure safety and efficacy.
• Enzyme Activity Assays: Utilized in studies to investigate the activity of UDP-glucuronosyltransferase (UGT) enzymes responsible for its formation.
• Toxicological Research: Employed in safety assessment studies to understand the potential role of metabolites in the overall toxicity profile of the parent drug.

Basic Information

Product Name	Bazedoxifene 4’-β-D-Glucuronide
CAS No.	328933-64-8
Molecular Formula	C₃₀H₃₅NO₈
Molecular Weight	537.60 g/mol
Synonyms	Bazedoxifene 4'-Glucuronide; Bazedoxifene Glucuronide; Bazedoxifene 4'-O-β-D-Glucuronide; 1-[[4-[2-(Hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-yl β-D-Glucopyranosiduronic Acid; TSE-424 Glucuronide; WAY-140424 Glucuronide; Conjugated Metabolite of Bazedoxifene
EINECS	Contact for details

Quality Control

Our Bazedoxifene 4’-β-D-Glucuronide is manufactured under strict quality systems suitable for research and development use. Each batch is characterized and undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure high consistency and reliability. Comprehensive Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C, in a dry environment. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.