Description

Bazedoxifene 5-β-D-Glucuronide is a major, pharmacologically relevant metabolite of the selective estrogen receptor modulator (SERM) bazedoxifene. This compound is critical for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics (PK/ADME), and the development of bioanalytical methods. It serves as an essential reference standard for laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors, ensuring accurate quantification and characterization of bazedoxifene in biological matrices.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for quantitative analysis in drug development and regulatory submissions.
• Metabolite Identification & Profiling: Crucial for in vitro and in vivo ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand the metabolic fate of Bazedoxifene.
• Bioanalytical Method Development & Validation: Used to calibrate equipment (e.g., LC-MS/MS, HPLC) and validate assays for the accurate measurement of Bazedoxifene and its metabolites in plasma, serum, and urine.
• Pharmacokinetic (PK) Studies: Enables precise tracking of metabolite formation and elimination rates to build comprehensive PK models.
• Impurity Profiling: Acts as a known impurity or degradation product standard for the quality control of Bazedoxifene Active Pharmaceutical Ingredient (API).
• Clinical Research: Supports studies investigating inter-individual variability in drug metabolism and potential drug-drug interactions.

Basic Information

Product Name	Bazedoxifene 5-β-D-Glucuronide
CAS No.	328933-56-8
Molecular Formula	C₃₀H₃₅NO₈
Molecular Weight	537.60 g/mol
Synonyms	Bazedoxifene 5-O-β-D-Glucuronide; Bazedoxifene Glucuronide; 1-[4-[2-(Hexahydro-1H-azepin-1-yl)ethoxy]phenyl]-3-methyl-5-[[(1S)-1-phenylpropyl]oxy]-1H-indol-2-yl β-D-Glucopyranosiduronic Acid; TSE-424 Glucuronide; WAY-140424 Glucuronide; Bazedoxifene Metabolite; Conjugated Bazedoxifene
EINECS	Contact for details

Quality Control

Our Bazedoxifene 5-β-D-Glucuronide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and assay, LC-MS for identity confirmation, and residual solvent analysis to ensure it meets the stringent requirements for use as a reference standard. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.