Description

2,4-Difluoro-5-Nitrophenylboronic Acid is a high-value, multi-functional boronic acid derivative characterized by its unique substitution pattern. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science sectors who require precise molecular scaffolds for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting various therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a crucial boron-containing partner for forming carbon-carbon bonds, enabling the construction of complex biaryl structures common in modern drug candidates.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the biological activity of difluoro- and nitro-substituted aromatic systems.
• Material Science & OLED Development: Serves as a precursor for creating organic electronic materials, including ligands for metal-organic frameworks (MOFs) and emissive layers in organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Synthesis: Utilized in the design and synthesis of molecular probes and sensors for biochemical research and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for custom synthesis projects requiring specialized boronic acid derivatives.

Basic Information

Item	Details
Product Name	2,4-Difluoro-5-Nitrophenylboronic Acid
CAS No.	325986-11-6
Molecular Formula	C6H4BF2NO4
Molecular Weight	202.91 g/mol
Synonyms	(2,4-Difluoro-5-nitrophenyl)boronic acid; 5-Nitro-2,4-difluorophenylboronic acid; 2,4-Difluoro-5-nitrobenzeneboronic acid; Boronic acid, B-(2,4-difluoro-5-nitrophenyl)-; 325986-11-6; 2,4-Difluoro-5-nitrophenyl-B(OH)2
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-5-Nitrophenylboronic Acid is manufactured under a strict quality management system. We provide comprehensive analytical documentation, including a Certificate of Analysis (COA) with detailed results from HPLC, NMR, and other relevant tests to verify identity, purity, and conformity. Our quality protocols are designed to meet the stringent requirements of cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.