Description

Etoricoxib N'-Oxide is a key pharmaceutical intermediate and a specific oxidative metabolite of the selective COX-2 inhibitor, Etoricoxib. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of related active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers engaged in the production of advanced anti-inflammatory medications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis and research of Etoricoxib and its structural analogs.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to identify and quantify Etoricoxib metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Essential for studying the metabolic pathways, stability, and clearance mechanisms of COX-2 inhibitors.
• Impurity Profiling: Serves as a known impurity or degradation product reference standard for quality control and regulatory filing of Etoricoxib API.
• Biochemical Research: Used in in vitro studies to investigate the biological activity and selectivity of oxidative metabolites.
• Process Development: Aids in the development and optimization of synthetic routes for novel anti-inflammatory agents.

Basic Information

Item	Details
Product Name	Etoricoxib N'-Oxide
CAS No.	325855-71-8
Molecular Formula	C18H15ClN2O3S
Molecular Weight	374.84 g/mol
Synonyms	5-Chloro-2-(6-methylpyridin-3-yl)-3-[4-(methylsulfonyl)phenyl]pyridine 1-oxide; Etoricoxib N-Oxide; Etoricoxib Impurity N-Oxide; Etoricoxib Related Compound N-Oxide; L-791456 N-Oxide; MK-0663 N-Oxide; 3-Pyridinecarboxamide, 5-chloro-2-(6-methyl-3-pyridinyl)-N-[[4-(methylsulfonyl)phenyl]methyl]-, 1-oxide
EINECS	Contact for details

Quality Control

Our Etoricoxib N'-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.