Description

4-Chloro-2-Fluoro-5-Methylphenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a key intermediate for constructing complex molecules via the versatile Suzuki-Miyaura cross-coupling reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for drug discovery programs targeting a range of therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, enabling the creation of compounds with improved efficacy and environmental profiles.
• Material Science: Serves as a building block for advanced organic materials, including liquid crystals, organic light-emitting diodes (OLEDs), and polymers with specialized properties.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a boron-containing coupling partner in palladium-catalyzed cross-coupling reactions to form biaryl and other carbon-carbon bonds with high selectivity.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for methodology development and the construction of complex molecular architectures.
• Ligand Synthesis: Can be utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Chloro-2-Fluoro-5-Methylphenylboronic Acid
CAS No.	325786-09-2
Molecular Formula	C7H7BClFO2
Molecular Weight	187.39 g/mol
Synonyms	(4-Chloro-2-fluoro-5-methylphenyl)boronic acid; 2-Fluoro-4-chloro-5-methylbenzeneboronic acid; 4-Chloro-2-fluoro-5-methylbenzeneboronic acid; Boronic acid, B-(4-chloro-2-fluoro-5-methylphenyl)-; 325786-09-2; 4-Chloro-2-fluoro-5-methyl-phenylboronic acid
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-5-Methylphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using an inert atmosphere or desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.