Description

Zidovudine-13C CAS NO 325484-33-1 is a stable isotope-labeled analog of the antiviral drug Zidovudine (AZT), where a carbon-13 atom replaces a carbon-12 atom at a specific position in the molecular structure. This compound is an essential reference standard and internal standard for precise quantitative analysis in pharmaceutical research and development. It is primarily used by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method validation to ensure accurate and reliable measurement of Zidovudine in complex biological matrices.

Application

• Bioanalytical Method Development and Validation as a stable isotope-labeled internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS/MS).
• Pharmacokinetic and Pharmacodynamic (PK/PD) Studies to accurately quantify Zidovudine levels in plasma, serum, and other biological fluids.
• Drug Metabolism and Disposition Research for tracing metabolic pathways and identifying metabolites.
• Clinical Trial Support ensuring data integrity in bioanalysis for regulatory submissions to agencies like the FDA and EMA.
• Quality Control in Pharmaceutical Manufacturing for the assay and impurity profiling of Zidovudine active pharmaceutical ingredients (APIs) and finished dosage forms.
• Forensic and Anti-Doping Analysis for the definitive identification and quantification of the substance.

Basic Information

Product Name	Zidovudine-13C
CAS No.	325484-33-1
Molecular Formula	C1013CH13N5O4
Molecular Weight	268.25 g/mol (for 13C1 labeled form)
Synonyms	AZT-13C; 3'-Azido-3'-deoxythymidine-13C; Retrovir-13C; Azidothymidine-13C; 1-((2R,4S,5S)-4-Azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methyl-13C-pyrimidine-2,4(1H,3H)-dione; BW A509U-13C; Compound S-13C; ZDV-13C
EINECS	Contact for details

Quality Control

Our Zidovudine-13C is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment, chemical purity (by HPLC), and identification (by NMR and MS). We adhere to relevant GMP guidelines for reference standards, ensuring traceability, stability, and reliability for your critical research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or Certificate of Analysis. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C
Chemical Purity (by NMR)	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.