Description

(R)-(-)-4,12-Bis(Di(3,5-Xylyl)Phosphino)-[2.2]-Paracyclophane, Min. 95% Cth-(R)-3,5-Xylyl-Phanephos is a high-purity, chiral bisphosphine ligand of significant importance in asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in a variety of transition-metal-catalyzed reactions, enabling the production of single-enantiomer compounds. This ligand is essential for R&D and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for synthesizing advanced intermediates and active ingredients.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of dehydroamino acids, enamides, ketones, and other unsaturated substrates.
• Pharmaceutical Intermediate Synthesis: Critical for the production of chiral active pharmaceutical ingredients (APIs) and key synthetic building blocks.
• Agrochemical Manufacturing: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Enables asymmetric C-C bond-forming reactions, including cross-coupling and allylic substitution.
• Catalyst Screening & Development: A benchmark ligand in R&D for developing new catalytic processes and optimizing existing ones.
• Academic & Industrial Research: A valuable tool for studying mechanistic pathways and exploring new frontiers in asymmetric synthesis.

Basic Information

Product Name	(R)-(-)-4,12-Bis(Di(3,5-Xylyl)Phosphino)-[2.2]-Paracyclophane, Min. 95% Cth-(R)-3,5-Xylyl-Phanephos
CAS No.	325168-89-6
Molecular Formula	C58H56P2
Molecular Weight	814.99 g/mol
Synonyms	(R)-3,5-Xylyl-Phanephos; (R)-Phanephos; (R)-(-)-4,12-Bis[bis(3,5-dimethylphenyl)phosphino]-[2.2]paracyclophane; (R)-Xylyl-Phanephos; (R)-(-)-4,12-Bis(di-3,5-xylylphosphino)[2.2]paracyclophane; (R)-Bisphosphine Phanephos Ligand; CTH-(R)-XYLYL-PHANEPHOS; (R)-(-)-4,12-Bis(di(3,5-dimethylphenyl)phosphino)[2.2]paracyclophane
EINECS	Contact for details

Quality Control

Every batch of our (R)-3,5-Xylyl-Phanephos undergoes rigorous analytical testing to ensure it meets the high standards required for asymmetric synthesis. Our quality assurance protocol includes HPLC for chiral purity and assay, NMR for structural confirmation, and specific tests for moisture and residual solvents. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to moisture and oxygen, this product should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	Min. 95.0%
Chiral Purity (HPLC)	Min. 99.0% ee
Water Content (KF)	Max. 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.