Description

(S)-(+)-4,12-Bis(Di(3,5-Xylyl)Phosphino)-[2.2]-Paracyclophane, Cth-(S)-3,5-Xylyl-Phanephos is a high-value, chiral bisphosphine ligand belonging to the PhanePhos family, renowned for its exceptional stereoselectivity in asymmetric catalysis. This compound matters because it enables the production of enantiomerically pure intermediates and active pharmaceutical ingredients (APIs) with high efficiency and yield. It is critically needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for developing and scaling up chiral syntheses, particularly in hydrogenation and cross-coupling reactions.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of dehydroamino acids, enamides, ketones, and other prochiral substrates in API manufacturing.
• Pharmaceutical Intermediate Synthesis: Key catalyst component for creating chiral centers in complex drug molecules, including cardiovascular, central nervous system (CNS), and antiviral agents.
• Agrochemical Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Asymmetric Cross-Coupling Reactions: Facilitates C-C and C-X bond-forming reactions with high enantiomeric excess (ee).
• Fine Chemical and Flavor/Fragrance Synthesis: Enables the production of high-value chiral building blocks and aroma chemicals.
• Academic and Industrial R&D: A vital tool for methodological development in asymmetric catalysis and process chemistry.
• Catalyst Library Development: Serves as a benchmark ligand in high-throughput screening for new catalytic transformations.

Basic Information

Item	Details
Product Name	(S)-(+)-4,12-Bis(Di(3,5-Xylyl)Phosphino)-[2.2]-Paracyclophane ,Cth-(S)-3,5-Xylyl-Phanephos
CAS No.	325168-88-5
Molecular Formula	C58H56P2
Molecular Weight	815.00 g/mol
Synonyms	(S)-3,5-Xylyl-PhanePhos; (S)-4,12-Bis[bis(3,5-dimethylphenyl)phosphino]-[2.2]paracyclophane; (S)-Xylyl-PhanePhos; (S)-3,5-XylPhanePhos; CTH-(S)-3,5-Xylyl-Phanephos; (S)-(+)-4,12-Bis[bis(3,5-xylyl)phosphino][2.2]paracyclophane; (S)-Bisphosphine PhanePhos ligand; (S)-3,5-Me2Ph-PhanePhos
EINECS	Contact for details

Quality Control

Our (S)-3,5-Xylyl-PhanePhos is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for reproducible catalytic performance. Each lot is characterized by advanced analytical techniques, including NMR, HPLC, and chiral analysis, to confirm identity, chemical purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its air-sensitive nature (easily oxidized), the product must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Specific Rotation [α]D20	Contact for details
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.