Description

Boc-2,4,6-Trifluoro-L-Phenylalanine is a protected, non-natural amino acid derivative of significant importance in advanced organic synthesis and pharmaceutical research. Its core value lies in the strategic incorporation of fluorine atoms and the tert-butoxycarbonyl (Boc) protecting group, enabling precise control over peptide structure and properties. This high-purity building block is essential for researchers and manufacturers developing novel peptide-based therapeutics, diagnostic agents, and materials science applications where enhanced metabolic stability, bioavailability, and specific binding characteristics are required.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of fluorinated peptide drugs and peptidomimetics, enhancing their metabolic stability and membrane permeability.
• Proteomics & Biochemical Research: Used in solid-phase peptide synthesis (SPPS) to introduce fluorinated phenylalanine residues for studying protein structure, function, and protein-protein interactions.
• Positron Emission Tomography (PET) Tracer Development: Serves as a precursor for synthesizing fluorine-18 labeled compounds used in medical imaging and diagnostic research.
• Agrochemical Research: Employed in the design and synthesis of novel fluorinated bioactive compounds with potential herbicidal or pesticidal activity.
• Material Science: Incorporated into specialty polymers and advanced materials to impart unique chemical and physical properties derived from the fluorine atoms.

Basic Information

Product Name	Boc-2,4,6-Trifluoro-L-Phenylalanine
CAS No.	324028-28-6
Molecular Formula	C₁₄H₁₆F₃NO₄
Molecular Weight	319.28 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-2,4,6-trifluoro-L-phenylalanine; Boc-2,4,6-trifluoro-L-Phe-OH; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(2,4,6-trifluorophenyl)propanoic acid; N-Boc-2,4,6-Trifluoro-L-phenylalanine; tert-Butyl (2S)-2-amino-3-(2,4,6-trifluorophenyl)propanoate; BOC-L-2,4,6-Trifluorophe; Fmoc-2,4,6-Trifluoro-L-phenylalanine precursor
EINECS	Contact for details

Quality Control

Our Boc-2,4,6-Trifluoro-L-Phenylalanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP manufacturing. Each lot undergoes comprehensive analytical testing including HPLC for purity and chiral integrity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.