Description

n-Acetyl-3-(3,4,5-Trifluorophenyl)-D-Alanine is a high-purity, non-natural amino acid derivative characterized by its trifluoromethylphenyl side chain and D-configuration. This compound is a critical chiral building block in the synthesis of advanced pharmaceutical intermediates, where its structural features impart desirable metabolic stability and bioavailability. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of protease inhibitors, enzyme modulators, and other bioactive molecules.
• Peptidomimetics: Used in the design and synthesis of peptide analogs to enhance stability and receptor binding affinity.
• Agrochemical Research: Serves as a building block for novel herbicides and pesticides, leveraging the properties of the fluorine atoms.
• Chemical Biology Probes: Employed in the development of labeled compounds and probes for studying biological pathways and enzyme functions.
• Material Science: Potential monomer or additive in specialized polymers where fluorine content is beneficial.

Basic Information

Product Name	n-Acetyl-3-(3,4,5-Trifluorophenyl)-D-Alanine
CAS No.	324028-12-8
Molecular Formula	C₁₁H₁₀F₃NO₃
Molecular Weight	261.20 g/mol
Synonyms	N-Acetyl-3-(3,4,5-trifluorophenyl)-D-alanine; (R)-2-Acetamido-3-(3,4,5-trifluorophenyl)propanoic acid; D-N-Acetyl-3-(3,4,5-trifluorophenyl)alanine; Ac-D-3,4,5-F₃-Phe-OH; 324028-12-8; (R)-2-Acetylamino-3-(3,4,5-trifluorophenyl)-propionic acid; N-Acetyl-D-3-(3,4,5-trifluorophenyl)alanine
EINECS	Contact for details

Quality Control

Our n-Acetyl-3-(3,4,5-Trifluorophenyl)-D-Alanine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de (D-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.