Description

(2S)-2-Amino-3-(tert-Butoxy)Propanamide Hydrochloride is a chiral, protected amino acid derivative of significant interest in advanced organic synthesis. This high-purity building block is crucial for the development of complex molecules, particularly in the pharmaceutical sector, where it serves as a key intermediate for peptide-based drugs and active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the synthesis of novel therapeutic compounds and chiral ligands.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of peptide-based Active Pharmaceutical Ingredients (APIs) and other bioactive molecules.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a protected amino acid moiety with a tert-butoxy side chain.
• Protease Inhibitor Research: Serves as a key component in the research and development of enzyme inhibitors targeting specific proteases.
• Chemical Biology & Proteomics: Employed in the design and synthesis of activity-based probes (ABPs) and other tools for studying enzyme function.
• Chiral Ligand Synthesis: Acts as a precursor for the development of chiral ligands and catalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity chiral intermediates.

Basic Information

Product Name	(2S)-2-Amino-3-(tert-Butoxy)Propanamide Hydrochloride
CAS No.	323587-47-9
Molecular Formula	C7H17ClN2O2
Molecular Weight	196.68 g/mol
Synonyms	L-2-Amino-3-(tert-butoxy)propanamide hydrochloride; (S)-2-Amino-3-(tert-butoxy)propanamide hydrochloride; tert-Butyl L-serinamide hydrochloride; 3-(tert-Butoxy)-L-alaninamide hydrochloride; (2S)-2-Amino-3-[(2-methylpropan-2-yl)oxy]propanamide hydrochloride; H-Ser(tBu)-NH2·HCl; L-Serine, amide, O-(1,1-dimethylethyl)-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our (2S)-2-Amino-3-(tert-Butoxy)Propanamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.