Description

(Glu32)-Charybdotoxin CAS NO 321854-18-6 is a site-directed, chemically modified analog of the potent potassium channel blocker charybdotoxin. This engineered peptide is a critical research tool for the detailed study of ion channel structure, function, and pharmacology. It is primarily utilized by academic research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neuroscience, cardiovascular research, and drug discovery targeting ion channels.

Application

• Ion Channel Research: A selective probe for investigating the biophysical properties and gating mechanisms of specific potassium (K+) channels, particularly Ca2+-activated K+ channels.
• Structure-Activity Relationship (SAR) Studies: Used to map toxin-channel interaction sites and understand the molecular determinants of binding affinity and selectivity.
• Pharmacological Characterization: Serves as a reference standard and blocking agent in electrophysiology assays (e.g., patch-clamp) to characterize novel compounds.
• Neuroscience Research: Tool for studying the role of specific K+ channels in neuronal excitability, synaptic transmission, and associated disease models.
• Cardiovascular Research: Applied in research on vascular tone and smooth muscle physiology where specific K+ channels are key regulators.
• Drug Discovery Screening: Used in high-throughput screening (HTS) campaigns to identify and validate new ion channel modulators.
• Bioconjugation & Probe Development: Acts as a scaffold for creating labeled (e.g., fluorescent, radioactive) derivatives for advanced imaging and binding studies.

Basic Information

Product Name	(Glu32)-Charybdotoxin
CAS No.	321854-18-6
Molecular Formula	C198H302N58O59S6
Molecular Weight	~ 4410.2 g/mol
Synonyms	Charybdotoxin (Glu32); Charybdotoxin, Glu(32)-; L-Glutamic acid-32-charybdotoxin; CTX-Glu32; [Glu32]Charybdotoxin; Potassium channel toxin α-KTx 1.1 (Glu32 variant); ShK-like peptide analog
EINECS	Contact for details

Quality Control

Our (Glu32)-Charybdotoxin is produced and analyzed under stringent conditions to ensure high purity, correct sequence, and consistent biological activity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency. We adhere to rigorous quality management practices suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical composition
Water Content (KF)	≤ 5.0 %
Biological Activity	Confirmed by functional assay (e.g., channel blockade)
Endotoxin Level	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.