Description

(D-Tyr5)-Triptorelin CAS NO 321709-35-7 is a synthetic peptide analog of the natural gonadotropin-releasing hormone (GnRH), specifically modified with a D-tyrosine substitution at the fifth position. This structural modification is critical for enhancing its metabolic stability and receptor binding affinity, making it a valuable tool in advanced biomedical research and development. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on endocrinology, oncology, and the development of novel therapeutic peptides.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel GnRH-based therapeutics.
• Endocrinology Studies: Used in preclinical research to study hormone regulation, receptor-ligand interactions, and the hypothalamic-pituitary-gonadal axis.
• Oncology Research: Investigated for applications in hormone-dependent cancers, such as prostate and breast cancer, due to its potential effects on hormone suppression.
• Peptide Chemistry & Biochemistry: Acts as a model compound for studying peptide stability, structure-activity relationships (SAR), and enzymatic degradation pathways.
• Analytical Standard: Employed as a high-purity calibrant in analytical methods like HPLC and LC-MS for quality control and method validation in peptide manufacturing.

Basic Information

Product Name	(D-Tyr5)-Triptorelin
CAS No.	321709-35-7
Molecular Formula	C₆₄H₈₂N₁₈O₁₂
Molecular Weight	1311.5 g/mol
Synonyms	D-Tyr5-Triptorelin; Triptorelin (D-Tyr5) analog; 5-D-Tyrosyl-triptorelin; Gonadorelin (5-D-Tyr) analog; P-Glu-His-Trp-Ser-Tyr-D-Tyr-Leu-Arg-Pro-Gly-NH₂; LHRH (D-Tyr5) analog; GnRH (D-Tyr5) agonist
EINECS	Contact for details

Quality Control

Our (D-Tyr5)-Triptorelin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and related substances. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.