Description

D-Phenylalanine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-β-Methyl-, (βr)- CAS NO 321524-81-6 is a specialized, optically active Fmoc-protected amino acid derivative. This high-purity building block is critical for the synthesis of complex peptides and peptidomimetics with specific stereochemical requirements. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of novel therapeutic agents and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled assembly of peptide chains, particularly those requiring the incorporation of non-natural or modified amino acids.
• Pharmaceutical Research: Serves as a crucial precursor in the discovery and development of peptide-based drugs, hormone analogs, and enzyme inhibitors.
• Peptidomimetic Design: Used to create stable, bioavailable analogs of natural peptides for enhanced therapeutic efficacy and metabolic stability.
• Bioconjugation: Employed in the synthesis of peptide tags, linkers, and carriers for targeted drug delivery systems and diagnostic agents.
• Chemical Biology Probes: Facilitates the study of protein-protein interactions and enzyme mechanisms through the creation of labeled or modified peptide sequences.
• Academic & Industrial R&D: A fundamental reagent for laboratories focused on organic synthesis, medicinal chemistry, and protein engineering.

Basic Information

Product Name	D-Phenylalanine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-β-Methyl-, (βr)-
CAS No.	321524-81-6
Molecular Formula	C26H25NO4
Molecular Weight	415.48 g/mol
Synonyms	Fmoc-β-Me-D-Phe-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylbutanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methyl-D-phenylalanine; Fmoc-3-methyl-D-phenylalanine; Fmoc-β-methyl-D-Phenylalanine; N-Fmoc-β-methyl-D-phenylalanine; Fmoc-D-β-methylphenylalanine
EINECS	Contact for details

Quality Control

Our D-Phenylalanine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-β-Methyl-, (βr)- is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.