Description

Amiodarone n-Oxide is a key pharmaceutical intermediate and metabolite of the antiarrhythmic drug amiodarone. This compound is of significant interest in pharmaceutical research and development for studying drug metabolism and pharmacokinetics. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the synthesis of active pharmaceutical ingredients (APIs) and the development of analytical reference standards.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis and research of amiodarone and related antiarrhythmic compounds.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical laboratories for drug metabolism and pharmacokinetic (DMPK) studies.
• Active Pharmaceutical Ingredient (API) Research: Serves as a precursor or subject in the development and characterization of new cardiovascular drug formulations.
• Quality Control & Analytical Testing: Employed in HPLC, LC-MS, and other chromatographic methods for method development, validation, and impurity profiling.
• Biochemical Research: Used in in-vitro and in-vivo studies to investigate the pharmacological activity and metabolic pathways of amiodarone derivatives.

Basic Information

Product Name	Amiodarone n-Oxide
CAS No.	318267-30-0
Molecular Formula	C25H29I2NO4
Molecular Weight	669.31 g/mol
Synonyms	Amiodarone N-Oxide; Amiodarone Oxide; 2-Butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone N-oxide; 4-[2-(Diethylamino)ethoxy]-3,5-diiodobenzoyl-2-butyl-3-benzofuranyl ketone N-oxide; Benzofuran, 2-butyl-3-[4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl]-, 1-oxide
EINECS	Contact for details

Quality Control

Our Amiodarone n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and pharmaceutical-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.