Description

1-Chloro-3-Fluoro-4-(Trifluoromethoxy)Benzene is a high-purity fluorinated aromatic building block of significant commercial importance. This compound is valued for its unique combination of halogen and trifluoromethoxy substituents, which impart specific electronic and steric properties critical for advanced synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Serves as a crucial building block for modern herbicides and fungicides, where the fluorine and trifluoromethoxy groups enhance biological activity and environmental stability.
• Liquid Crystal Materials: Used in the research and production of fluorinated liquid crystals for advanced display technologies.
• Organic Electronics: Acts as a precursor in the synthesis of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, improving their chemical resistance and surface properties.
• Chemical Research: A versatile reagent in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution for discovering new chemical entities.

Basic Information

Product Name	1-Chloro-3-Fluoro-4-(Trifluoromethoxy)Benzene
CAS No.	317337-16-9
Molecular Formula	C7H3ClF4O
Molecular Weight	214.55 g/mol
Synonyms	4-Chloro-2-Fluoro-1-(Trifluoromethoxy)Benzene; 2-Fluoro-4-Chloro-1-(Trifluoromethoxy)Benzene; 1-Chloro-3-Fluoro-4-(Trifluoromethoxy) Benzene; 3-Fluoro-4-(Trifluoromethoxy)Chlorobenzene; 4-(Trifluoromethoxy)-1-Chloro-3-Fluorobenzene; Benzene, 1-chloro-3-fluoro-4-(trifluoromethoxy)-; 317337-16-9
EINECS	Contact for details

Quality Control

Our 1-Chloro-3-Fluoro-4-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. The compound is compatible with standard organic solvent containers.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.