Description

Psalmotoxin 1 is a highly selective and potent peptide toxin that acts as an inhibitor of Acid-Sensing Ion Channel 1a (ASIC1a). This compound is a critical research tool for neuropharmacology and ion channel studies, enabling the investigation of pain signaling, ischemic stroke, and neurological disorders. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience and novel therapeutic discovery.

Application

• Neuroscience Research: A selective pharmacological tool for studying the role of ASIC1a channels in synaptic transmission, plasticity, and neuronal excitability.
• Pain Pathway Investigation: Used to probe the mechanisms of acid-induced pain and to validate ASIC1a as a potential target for analgesic drug development.
• Ischemic Stroke Models: Applied in preclinical research to understand and modulate neuronal damage following cerebral ischemia.
• Ion Channel Screening: Serves as a reference standard in high-throughput screening assays for identifying new ASIC modulators.
• Biochemical Assay Development: Used in the development and validation of binding assays and functional tests for ASIC channel activity.
• Academic & Pharmaceutical R&D: Essential for basic research and early-stage drug discovery programs targeting neurological conditions.

Basic Information

Product Name	Psalmotoxin 1
CAS No.	316808-68-1
Molecular Formula	C185H273N55O52S2
Molecular Weight	4089.6 g/mol
Synonyms	PcTx1; Psalmopoeus cambridgei toxin 1; ASIC1a inhibitor peptide; Acid-sensing ion channel 1a blocker; PcTX-1; PcTx-1; PcTx1 peptide; Venom peptide PcTx1
EINECS	Contact for details

Quality Control

Our Psalmotoxin 1 is produced under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency. We adhere to rigorous quality testing protocols to guarantee batch-to-batch consistency and reliability for your critical research needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and easily oxidized; it is recommended to store under an inert atmosphere after opening and to allow the vial to equilibrate to room temperature before use to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity (IC50)	Reported per batch COA
Single Peak on HPLC	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.