Description

Cyclopropanecarbonyl Chloride, 2,3-Difluoro-1-Methyl- (9Ci) is a high-value, multifunctional fluorinated building block essential for advanced organic synthesis. Its core value lies in the cyclopropane ring and acid chloride functionality, which enable efficient derivatization and incorporation of the difluoromethylcyclopropyl moiety into complex target molecules. This compound is critically needed by R&D and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, where its unique steric and electronic properties can modulate biological activity, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Active Ingredient Precursor: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluorocyclopropyl group enhances bioactivity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated monomers and polymers to impart unique properties like chemical resistance, low surface energy, and thermal stability.
• Fluorine Chemistry & SAR Studies: An indispensable tool for structure-activity relationship (SAR) studies, allowing medicinal chemists to explore the "fluorine effect" in a constrained, three-dimensional framework.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 2,3-Difluoro-1-Methyl- (9Ci)
CAS No.	315690-85-8
Molecular Formula	C5H5ClF2O
Molecular Weight	154.54 g/mol
Synonyms	2,3-Difluoro-1-methylcyclopropanecarbonyl chloride; 1-Methyl-2,3-difluorocyclopropanecarboxylic acid chloride; (1-Methyl-2,3-difluorocyclopropyl)carbonyl chloride; 2,3-Difluoro-1-methylcyclopropanecarboxylic acid chloride; 2,3-Difluoro-1-methylcyclopropanecarboxyl chloride
EINECS	Contact for details

Quality Control

Every batch of Cyclopropanecarbonyl Chloride, 2,3-Difluoro-1-Methyl- (9Ci) undergoes rigorous analytical testing to ensure identity, purity, and consistency suitable for demanding R&D and scale-up applications. Our quality commitment includes in-process controls and final release testing via advanced chromatographic and spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening and protected from moisture. Store away from strong bases, oxidizers, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.