Description

Amyloid Beta/A4 Protein Precursor770 (135-155) is a synthetic peptide fragment corresponding to residues 135-155 of the 770 isoform of the Amyloid Precursor Protein (APP). This high-purity research compound is critical for advancing the understanding of Alzheimer's disease pathology and related neurodegenerative mechanisms. It serves as an essential tool for scientists in pharmaceutical R&D, academic institutions, and diagnostic development, enabling targeted studies on amyloid beta peptide formation, aggregation, and neurotoxicity.

Application

• Neuroscience Research: Fundamental studies on the proteolytic processing of APP and the generation of amyloid-beta peptides.
• Drug Discovery & Screening: Used as a reference standard or target in assays to identify and validate potential therapeutic inhibitors of amyloid aggregation.
• Antibody Development & Characterization: Critical for the production, purification, and epitope mapping of antibodies targeting specific regions of the APP protein.
• Biomarker Research: Investigation into APP-derived fragments as potential biomarkers for Alzheimer's disease progression in biological fluids.
• In Vitro & Cell-Based Assays: Employed in cellular models to study the effects of APP fragments on neuronal health, signaling, and toxicity.
• Diagnostic Kit Development: Utilized as a calibrated antigen in the development of immunoassays (ELISA, Western Blot) for research and clinical diagnostics.

Basic Information

Product Name	Amyloid Beta/A4 Protein Precursor770 (135-155)
CAS No.	315229-44-8
Molecular Formula	C99H155N29O30
Molecular Weight	~2240.5 g/mol
Synonyms	APP770 (135-155); Amyloid Beta Precursor Protein 770 (135-155); Amyloid Beta A4 Protein Precursor (770) fragment 135-155; AβPP770 (135-155); APP (770) Peptide (135-155); Synthetic APP Fragment; Alzheimer's Disease Research Peptide
EINECS	Contact for details

Quality Control

Every batch of Amyloid Beta/A4 Protein Precursor770 (135-155) is manufactured under stringent conditions and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Our quality assurance protocol includes multiple orthogonal methods, and we provide full traceability and documentation. Certificates of Analysis (COA) detailing purity, HPLC profile, mass spectrometry (MS) data, and amino acid analysis are available for all shipments to support your research compliance and reproducibility requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture absorption. Aliquot into single-use vials after reconstitution to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Within ±10% of theoretical
Peptide Content	≥ 80%
Solubility	Soluble in water or dilute acetic acid
Single Impurity (HPLC)	≤ 1.0%
Water Content (K.F.)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.