Description

1-Bromo-4-Fluoro-2-Methoxy-5-Methylbenzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in its versatile reactivity, where the bromine and fluorine substituents serve as orthogonal handles for selective cross-coupling and functional group transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring specific halogenated aromatic cores.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides.
• Material Science Precursor: Serves as a monomer or building block for specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions.
• Fluorine Chemistry: The fluorine substituent is utilized to modulate lipophilicity, metabolic stability, and bioavailability in drug design.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D in exploring new synthetic methodologies.

Basic Information

Product Name	1-Bromo-4-Fluoro-2-Methoxy-5-Methylbenzene
CAS No.	314298-15-2
Molecular Formula	C8H8BrFO
Molecular Weight	219.05 g/mol
Synonyms	4-Bromo-2-fluoro-5-methoxytoluene; 2-Bromo-5-fluoro-4-methoxytoluene; 2-Fluoro-4-methoxy-5-methylbromobenzene; 5-Methyl-2-methoxy-4-bromofluorobenzene; 1-Bromo-4-fluoro-2-methoxy-5-methyl-benzene; 2-Methoxy-5-methyl-4-bromofluorobenzene; Benzene, 1-bromo-4-fluoro-2-methoxy-5-methyl-
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Fluoro-2-Methoxy-5-Methylbenzene is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee reliable performance in your sensitive synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.