Description

9α-Bromobudesonide is a key brominated derivative and synthetic intermediate of the corticosteroid budesonide. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel steroid-based drug candidates. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of advanced anti-inflammatory and respiratory therapeutics. The precise modification at the 9-alpha position makes it a critical building block for structure-activity relationship (SAR) studies and the creation of new chemical entities.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel corticosteroid analogs and active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to explore new therapeutic pathways for inflammatory diseases.
• Reference Standard: Serves as an analytical standard in quality control laboratories for the identification and quantification of related substances.
• Process Chemistry: Employed in scale-up and process optimization for the manufacturing of steroid-based pharmaceuticals.
• Academic Research: Utilized in university and institutional labs for studying steroid biochemistry and synthetic methodologies.

Basic Information

Product Name	9α-Bromobudesonide
CAS No.	313474-59-8
Molecular Formula	C25H33BrO6
Molecular Weight	509.44 g/mol
Synonyms	9α-Bromo-11β,21-dihydroxy-16α,17α-butylidenedioxypregna-1,4-diene-3,20-dione; 9α-Bromo-16α,17α-butylidenedioxy-11β,21-dihydroxypregna-1,4-diene-3,20-dione; 9α-Bromobudesonide; Budesonide 9α-Bromo Derivative; 9-Bromobudesonide
EINECS	Contact for details

Quality Control

Our 9α-Bromobudesonide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.