Description

Leptin (138-167) (Human) is a synthetic peptide fragment corresponding to amino acids 138-167 of the human leptin protein. This high-purity peptide is a critical research tool for studying the structure, function, and signaling mechanisms of leptin, a key hormone in regulating energy balance and metabolism. It is essential for researchers and developers in the fields of endocrinology, metabolic disease research, and pharmaceutical development, particularly for investigating receptor binding and developing diagnostic assays.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of leptin's biological activity and receptor interaction mechanisms.
• Metabolic Pathway Analysis: Critical for in vitro and ex vivo experiments aimed at understanding the role of specific leptin domains in appetite regulation and energy homeostasis.
• Antibody Production & Immunoassay Development: Serves as a key antigen for generating specific antibodies and for use in ELISA and other immunoassay platforms.
• Pharmaceutical R&D: Employed in the screening and development of potential therapeutics targeting the leptin signaling pathway for obesity and metabolic disorders.
• Cell Signaling Studies: Utilized to stimulate or inhibit leptin-specific pathways in cell culture models to elucidate downstream effects.
• Quality Control: Acts as a system suitability standard in the analytical testing of related biopharmaceutical products.

Basic Information

Product Name	Leptin (138-167) (Human)
CAS No.	313338-97-5
Molecular Formula	C152H246N44O45S
Molecular Weight	3417.9 g/mol
Synonyms	Human Leptin Fragment 138-167; Leptin (138-167); Obese Protein (138-167) (Human); Leptin Peptide (138-167); LEP (138-167); OB Peptide (138-167); Leptin 30-mer; Recombinant Human Leptin Fragment
EINECS	Contact for details

Quality Control

Every batch of Leptin (138-167) (Human) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system adheres to GMP principles for research-grade peptides. Full characterization is performed using HPLC, MS, and amino acid analysis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Amino Acid Composition	Conforms to theoretical values
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.