Description

Human β-Amyloid Protein 42 (1-7) is a specific, high-purity synthetic peptide fragment corresponding to the first seven amino acids of the full-length Aβ42 protein. This compound is a critical research tool for studying the mechanisms of amyloid plaque formation and neurotoxicity associated with Alzheimer's disease. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers focused on neurodegenerative disorders and therapeutic target validation.

Application

• Neuroscience Research: Used as a reference standard and control in studies investigating the aggregation kinetics and toxicity of β-amyloid peptides.
• Drug Discovery & Screening: Serves as a key substrate or target in high-throughput assays to identify and evaluate potential inhibitors of amyloid-beta aggregation.
• Antibody Development & Validation: Essential for the production, characterization, and specificity testing of antibodies designed to target the N-terminal region of Aβ42.
• Diagnostic Assay Calibration: Employed as a precise calibrator in ELISA, Western Blot, and other immunoassays for the quantitative detection of amyloid-beta species.
• Biomarker Studies: Facilitates research into the role of specific Aβ fragments as potential biomarkers for Alzheimer's disease progression.
• Structural Biology: Used in NMR and X-ray crystallography studies to determine the structural properties of amyloid-beta fragments.

Basic Information

Product Name	Human β-Amyloid Protein 42 (1-7)
CAS No.	310901-06-5
Molecular Formula	C34H47N9O11
Molecular Weight	757.8 g/mol
Synonyms	Aβ42 (1-7); Amyloid β-Protein (1-7); Amyloid β-Peptide (1-7); DAEFRHD; H-Asp-Ala-Glu-Phe-Arg-His-Asp-OH; β-Amyloid (1-7); Aβ (1-7); Human Amyloid Beta Peptide 1-7
EINECS	Contact for details

Quality Control

Every batch of Human β-Amyloid Protein 42 (1-7) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment aligns with standards suitable for critical research applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), molecular weight confirmation (by MS), and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular ion peak matches theoretical mass
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.