Description

2-Chloro-6-Fluorobromobenzene is a high-purity, multi-halogenated aromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules with precise electronic and steric properties. This compound is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorine-containing drugs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides where the halogen pattern enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-based electronic materials used in display technologies and organic light-emitting diodes.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to form biaryl and complex aromatic systems.
• Ligand & Catalyst Development: Employed in the preparation of specialized phosphine and N-heterocyclic carbene (NHC) ligands for asymmetric catalysis.
• Polymer & Resin Modifier: Incorporated into polymer backbones to alter thermal stability, refractive index, and chemical resistance of high-performance engineering plastics.

Basic Information

Product Name	2-Chloro-6-Fluorobromobenzene
CAS No.	309721-44-6
Molecular Formula	C6H3BrClF
Molecular Weight	209.44 g/mol
Synonyms	1-Bromo-2-chloro-3-fluorobenzene; 3-Fluoro-2-chlorobromobenzene; 2-Chloro-3-fluorophenyl bromide; 2-Chloro-6-fluorophenyl bromide; Bromo(2-chloro-6-fluorophenyl); Benzene, 1-bromo-2-chloro-3-fluoro-; (2-Chloro-6-fluorophenyl)bromide
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-6-Fluorobromobenzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the exacting standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by GC, HPLC, and NMR is supplied with each shipment, ensuring full traceability and compliance with cGMP principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed in a dry environment to prevent moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.5%
Water Content (KF)	≤ 0.2%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.