Description

Dsg-Peg 2000 is a specialized, high-purity polyethylene glycol derivative, identified by CAS NO 308805-39-2. This compound is engineered to provide superior performance as a functional linker or modifier in advanced pharmaceutical and bioconjugation applications. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, high-quality PEGylation reagents to enhance the pharmacokinetic properties of therapeutic agents.

Application

• Pharmaceutical PEGylation: Acts as a crucial linker for modifying proteins, peptides, and oligonucleotides to improve solubility, stability, and circulation half-life.
• Bioconjugation Chemistry: Used for attaching targeting ligands, dyes, or drug molecules in the development of antibody-drug conjugates (ADCs) and diagnostic probes.
• Polymer Therapeutics: Serves as a building block for creating advanced drug delivery systems, including polymeric micelles and nanoparticles.
• Surface Modification: Applied to functionalize biomaterial surfaces (e.g., implants, sensors) to enhance biocompatibility and reduce non-specific binding.
• Cross-linking Agent: Utilized in the synthesis of hydrogels and other three-dimensional polymer networks for tissue engineering and controlled release.
• Research & Development: A key reagent in life science research for studying biomolecular interactions and developing novel therapeutic modalities.

Basic Information

Product Name	Dsg-Peg 2000
CAS No.	308805-39-2
Molecular Formula	Contact for details
Molecular Weight	~2000 g/mol (nominal)
Synonyms	DSG-PEG2000; Disuccinimidyl Glutarate PEG 2000; PEG2000-DSG; N-Hydroxysuccinimide ester of PEG-glutaric acid; NHS-PEG2000-GA; Poly(ethylene glycol) bis(succinimidyl glutarate) average Mn 2000; PEGylated DSG crosslinker; Succinimidyl ester functionalized PEG 2000
EINECS	Contact for details

Quality Control

Our Dsg-Peg 2000 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and end-group analysis to ensure it meets the high standards required for sensitive bioconjugation work. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive); containers must be kept sealed under desiccant to prevent hydrolysis of the active NHS ester groups. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥95%
Molecular Weight (GPC)	1900 - 2100 g/mol (Mn)
Polydispersity Index (PDI)	≤1.05
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Functional Group Substitution	>90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.