Description

Tumor Necrosis Factor-α (TNF-α) is a critical cytokine protein that plays a central role in regulating immune cell function, inflammation, and apoptosis. Its high-purity form is essential for advanced biomedical research and therapeutic development. This product is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotech companies focused on immunology, oncology, and autoimmune disease studies.

Application

• Biomedical Research: Used as a key reagent in cell-based assays to study inflammatory pathways, immune response modulation, and programmed cell death (apoptosis).
• Drug Discovery & Development: Serves as a target or tool compound for screening and validating potential therapeutic agents, including biologics and small molecule inhibitors for autoimmune diseases.
• Diagnostic Development: Employed in the calibration and development of immunoassays (e.g., ELISA) and biosensors for the quantitative detection of TNF-α in clinical samples.
• Cell Culture & Stimulation: Acts as a potent stimulant in vitro to induce inflammatory responses in various cell lines, such as macrophages, fibroblasts, and endothelial cells.
• Standard Reference Material: Provides a purified standard for quality control and assay validation in pharmaceutical manufacturing and clinical testing laboratories.

Basic Information

Product Name	Tumor Necrosis Factor-α
CAS No.	308079-78-9
Molecular Formula	C642H987N169O198S9
Molecular Weight	Approx. 17.5 kDa (monomeric, soluble form)
Synonyms	TNF-α; Tumor Necrosis Factor Alpha; Cachectin; TNF; TNFA; TNF Superfamily Member 2; TNF-a; Tumor Necrosis Factor Ligand Superfamily Member 2; Differentiation-Inducing Factor (DIF); Necrosin; Macrophage Cytotoxin; TNLG1F
EINECS	Contact for details

Quality Control

Our Tumor Necrosis Factor-α is produced and tested under stringent conditions to ensure the highest standards of purity and biological activity, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, endotoxin levels, and biological activity via standardized bioassays. We adhere to relevant quality management principles to ensure batch-to-batch consistency and reliability.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to minimize freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under inert, dry conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Single band corresponding to ~17.5 kDa
Purity (HPLC)	≥ 95%
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity (Cell-based assay)	Contact for details
Solubility	Soluble in sterile, endotoxin-free water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.