Description

(R)-(+)-1-Chloro-3-(4-Fluorophenoxy)-2-Propanol is a high-purity chiral building block and key pharmaceutical intermediate. This compound matters for its role in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in the β-blocker and adrenergic agent classes. It is needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop or manufacture optically active compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiomerically pure β-adrenergic blocking agents (β-blockers).
• Agrochemical Synthesis: Used in the research and development of chiral herbicides and pesticides.
• Asymmetric Synthesis: Serves as a versatile building block for constructing complex molecules with defined stereochemistry in medicinal chemistry.
• Chemical Research: A valuable reagent for academic and industrial research into new chiral methodologies and pharmacologically active compounds.
• Process Chemistry: Employed in the scale-up and optimization of manufacturing routes for target APIs requiring the (R)-enantiomer configuration.

Basic Information

Product Name	(R)-(+)-1-Chloro-3-(4-Fluorophenoxy)-2-Propanol
CAS No.	307532-04-3
Molecular Formula	C9H10ClFO2
Molecular Weight	204.63 g/mol
Synonyms	(R)-1-Chloro-3-(4-fluorophenoxy)-2-propanol; (R)-(+)-1-Chloro-3-(p-fluorophenoxy)-2-propanol; (R)-4-Fluorophenoxy-3-chloro-2-propanol; (R)-Chlorohydrin of 4-fluorophenoxypropylene oxide; (R)-3-Chloro-1-(4-fluorophenoxy)-2-propanol; (R)-Fenoxonil intermediate; (R)-enantiomer of 1-Chloro-3-(4-fluorophenoxy)-2-propanol
EINECS	Contact for details

Quality Control

Our (R)-(+)-1-Chloro-3-(4-Fluorophenoxy)-2-Propanol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with customer specifications and industry standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storage under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (R-enantiomer)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.