Description

1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, A-(2-Carboxyethyl)-, 1,4,7,10-Tetrakis(1,1-Dimethylethyl) Ester is a key protected intermediate in the synthesis of advanced macrocyclic chelating agents. This compound is critically important for the development of high-performance contrast agents used in medical imaging, particularly magnetic resonance imaging (MRI). It is primarily needed by research institutions, pharmaceutical development companies, and fine chemical manufacturers specializing in diagnostic and therapeutic radiopharmaceuticals.

Application

• Pharmaceutical Intermediate: A crucial protected precursor for synthesizing DOTA and DOTA-like macrocyclic ligands used in MRI contrast agents (Gadolinium-based).
• Radiopharmaceutical Development: Serves as a building block for chelators that bind radioisotopes (e.g., Lutetium-177, Yttrium-90) for targeted cancer therapy and diagnostic imaging.
• Chemical Research: Used in academic and industrial R&D to explore new metal complexes for catalysis, sensing, and material science applications.
• Contrast Agent Manufacturing: Enables the scalable production of high-purity, clinically approved gadolinium chelates by providing a controlled synthetic pathway.
• Bioconjugation Chemistry: The tert-butyl ester protected carboxylic acid groups allow for selective deprotection and conjugation to antibodies, peptides, or other targeting molecules.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, A-(2-Carboxyethyl)-, 1,4,7,10-Tetrakis(1,1-Dimethylethyl) Ester
CAS No.	306776-79-4
Molecular Formula	C40H72N4O12
Molecular Weight	801.02 g/mol
Synonyms	DO3A-tris(t-butyl ester) monoacetic acid; 2,2',2''-(10-(2-((tert-Butoxycarbonyl)methyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid tris(tert-butyl) ester; (α-(2-Carboxyethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid 1,4,7-tris(tert-butyl) ester; DO3A-tBu3; Protected DO3A monoacid; tert-Butyl DO3A ester; Precursor to MS-325 (Vasovist) chelator; Macrocyclic chelator intermediate
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for sensitive pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support development under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.