Description

tert-Butyl cis-4-[n-Methoxy-n-(Methylcarbamoyl)Cyclohexyl]Carbamate is a sophisticated carbamate-protected intermediate featuring a cis-configured cyclohexyl ring with methoxy and methylcarbamoyl substituents. This compound is of significant value in pharmaceutical research and development, serving as a critical building block for the synthesis of complex bioactive molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for constructing novel drug candidates, particularly those targeting neurological or metabolic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Protease Inhibitor Research: Used in the development of novel inhibitors for enzymes like dipeptidyl peptidase-4 (DPP-4) or similar targets.
• Peptidomimetic Chemistry: Serves as a constrained, non-natural amino acid analog for creating stable peptide mimics.
• Medicinal Chemistry Exploration: Enables structure-activity relationship (SAR) studies around the cyclohexyl scaffold for optimizing drug potency and selectivity.
• Process Chemistry: Employed in route scouting and scale-up optimization for cost-effective API manufacturing.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific research projects requiring high-purity advanced intermediates.

Basic Information

Product Name	tert-Butyl cis-4-[n-Methoxy-n-(Methylcarbamoyl)Cyclohexyl]Carbamate
CAS No.	304873-79-8
Molecular Formula	C15H28N2O4
Molecular Weight	300.40 g/mol
Synonyms	tert-Butyl (cis-4-{[(methoxy)(methylcarbamoyl)amino]methyl}cyclohexyl)carbamate; 4-[[(Methoxy)(methylcarbamoyl)amino]methyl]cyclohexylcarbamic acid tert-butyl ester (cis-); cis-4-({[(tert-Butoxy)carbonyl]amino}methyl)-N-methoxy-N-methylcyclohexanecarboxamide; BOC-cis-ACCA(OMe, NMe); (cis-4-{[(Methoxy)(methylcarbamoyl)amino]methyl}cyclohexyl)carbamic Acid 1,1-Dimethylethyl Ester; tert-Butyl N-[(cis-4-{[methoxy(methylcarbamoyl)amino]methyl}cyclohexyl)]carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl cis-4-[n-Methoxy-n-(Methylcarbamoyl)Cyclohexyl]Carbamate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing specifications such as chiral purity, HPLC assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% cis-isomer
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.