Description

1H-Imidazole-5-Carboxamide, n-(1,1-Dimethylethyl)- is a high-purity, tert-butyl-substituted imidazole derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a sterically hindered, nucleophilic nitrogen center essential for constructing complex heterocyclic frameworks and active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new molecular entities and fine-tuning material properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly those targeting enzyme inhibition or receptor modulation.
• Agrochemical Synthesis: Used in the production of advanced fungicides, herbicides, and plant growth regulators that require specific heterocyclic cores.
• Ligand & Catalyst Precursor: Serves as a precursor for N-heterocyclic carbene (NHC) ligands and other organocatalysts used in asymmetric synthesis and polymerization reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers, ionic liquids, and metal-organic frameworks (MOFs) with tailored properties.
• Chemical Biology Probe: Utilized as a scaffold for developing molecular probes and biochemical tools to study biological pathways.

Basic Information

Product Name	1H-Imidazole-5-Carboxamide, n-(1,1-Dimethylethyl)-
CAS No.	304457-87-2
Molecular Formula	C8H13N3O
Molecular Weight	167.21 g/mol
Synonyms	N-tert-Butyl-1H-imidazole-5-carboxamide; 5-Carbamoylimidazole, N-tert-butyl-; 1H-Imidazole-5-carboxamide, N-(1,1-dimethylethyl)-; N-(tert-Butyl)-1H-imidazole-5-carboxamide; tert-Butylimidazole-5-carboxamide; 304457-87-2; N-(tert-Butyl)imidazole-5-carboxamide
EINECS	Contact for details

Quality Control

Our 1H-Imidazole-5-Carboxamide, n-(1,1-Dimethylethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider maintaining the material under an inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.