Description

2-(Dicyclohexylphosphino)-2'-Hydroxybiphenyl CAS NO 304435-67-4 is a specialized organophosphorus ligand widely utilized in transition metal catalysis. This compound matters for its ability to facilitate challenging cross-coupling and other metal-catalyzed reactions with high efficiency and selectivity. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials industries for developing novel synthetic pathways and optimizing production processes.

Application

• Catalyst Ligand for Cross-Coupling Reactions: A key component in Buchwald-Hartwig amination, Suzuki-Miyaura, and related C-C/C-N bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: Enables the efficient and selective construction of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Product Development: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring precise molecular architecture.
• Material Science Research: Facilitates polymerization and the creation of functional organic materials and polymers.
• Asymmetric Catalysis: Employed in the development of chiral catalysts for the production of enantiomerically pure compounds.
• Academic and Industrial R&D: Serves as a valuable tool for methodological development in synthetic organic chemistry laboratories.

Basic Information

Product Name	2-(Dicyclohexylphosphino)-2'-Hydroxybiphenyl
CAS No.	304435-67-4
Molecular Formula	C24H31OP
Molecular Weight	366.48 g/mol
Synonyms	2-(Dicyclohexylphosphino)-2'-hydroxy-1,1'-biphenyl; 2'-Hydroxy-2-(dicyclohexylphosphino)biphenyl; Dicyclohexyl(2'-hydroxy[1,1'-biphenyl]-2-yl)phosphine; Biphenylphosphine ligand; DavePhos (common name for related ligands, often used in context); Phosphine ligand; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of 2-(Dicyclohexylphosphino)-2'-Hydroxybiphenyl is produced and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive catalytic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep away from oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.