Description

((2,4,6 Tri-Isopropyl)Phenyl)Di-Cyclohexylphosphine is a sterically demanding, electron-rich monodentate phosphine ligand, a key component in modern transition metal catalysis. Its primary value lies in enabling highly efficient and selective cross-coupling reactions, which are fundamental to constructing complex organic molecules. This ligand is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require robust catalytic systems for challenging synthetic transformations.

Application

• Cross-Coupling Catalysis: As a superior ligand for palladium-catalyzed Suzuki-Miyaura, Buchwald-Hartwig amination, and Negishi couplings.
• Pharmaceutical Intermediate Synthesis: For the efficient and selective construction of C-C, C-N, and C-O bonds in active pharmaceutical ingredient (API) development.
• Agrochemical Manufacturing: Used in the synthesis of complex, bioactive molecules for crop protection agents.
• Material Science Research: Employed in the development of organic electronic materials, polymers, and ligands for novel metal complexes.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new catalytic pathways in organic synthesis.
• Scale-up Process Chemistry: Suitable for optimization and scale-up of catalytic processes from laboratory to pilot plant scale due to its stability.

Basic Information

Product Name	((2,4,6 Tri-Isopropyl)Phenyl)Di-Cyclohexylphosphine
CAS No.	303111-96-8
Molecular Formula	C27H47P
Molecular Weight	402.63 g/mol
Synonyms	Di-cyclohexyl(2,4,6-triisopropylphenyl)phosphine; DiCyclohexyl(2,4,6-Triisopropylphenyl)Phosphine; (2,4,6-Triisopropylphenyl)dicyclohexylphosphine; Dicyclohexyl(2,4,6-triisopropylphenyl)phosphane; Tris(2,4,6-triisopropylphenyl)phosphine derivative; TippCyP; TippCyphos; Buchwald-type phosphine ligand
EINECS	Contact for details

Quality Control

Our production of ((2,4,6 Tri-Isopropyl)Phenyl)Di-Cyclohexylphosphine adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. Every lot is fully characterized by NMR (1H, 13C, 31P), HPLC, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, separate from oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
31P NMR Purity	≥ 98.0%
Melting Point	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.