Description

1-Ethynyl-2,4-Difluorobenzene 97 is a high-purity, multi-functional aromatic building block characterized by its terminal alkyne and difluorinated benzene ring. This compound matters for its role as a key synthon in modern organic synthesis, enabling efficient cross-coupling reactions and the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications such as drug discovery, ligand synthesis, and the creation of specialty polymers.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorine-containing drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides where the difluorophenyl and alkyne groups impart specific biological activity.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Catalyst & Ligand Development: Employed in the design and synthesis of novel organometallic catalysts and phosphine-type ligands for asymmetric catalysis.
• Click Chemistry: An ideal substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, facilitating the modular construction of complex molecules.
• Chemical Research: A versatile reagent in academic and industrial R&D for exploring new synthetic methodologies and constructing molecular libraries.

Basic Information

Item	Detail
Product Name	1-Ethynyl-2,4-Difluorobenzene 97
CAS No.	302912-34-1
Molecular Formula	C8H4F2
Molecular Weight	138.11 g/mol
Synonyms	2,4-Difluoroethynylbenzene; 2,4-Difluorophenylacetylene; 1-Ethynyl-2,4-difluorobenzene; 2,4-Difluoro-1-ethynylbenzene; (2,4-Difluorophenyl)ethyne; Ethynyl-2,4-difluorobenzene
EINECS	Contact for details

Quality Control

Our 1-Ethynyl-2,4-Difluorobenzene 97 is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure the specified purity and identity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.