Description

2,5-Bis(Trifluoromethyl)Phenylacetic Acid is a high-value fluorinated aromatic building block characterized by its phenylacetic acid core flanked by two strong electron-withdrawing trifluoromethyl groups. This unique structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where enhanced lipophilicity, metabolic stability, and electronic properties are required. It is primarily sought after by R&D and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel compounds.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in areas requiring fluorinated motifs for improved bioavailability and target binding.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl groups contribute to biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, influencing dielectric anisotropy and stability.
• Polymer Modification: Incorporated as a monomer or additive to create specialty polymers with unique surface properties, chemical resistance, and optical characteristics.
• Ligand & Catalyst Design: Utilized in organometallic chemistry to construct sophisticated ligands for catalysis, leveraging the steric and electronic influence of the CF3 groups.
• Chemical Research & Development: A versatile scaffold in medicinal and synthetic chemistry for exploring structure-activity relationships (SAR) and new synthetic methodologies.

Basic Information

Product Name	2,5-Bis(Trifluoromethyl)Phenylacetic Acid
CAS No.	302912-02-3
Molecular Formula	C10H6F6O2
Molecular Weight	272.15 g/mol
Synonyms	[2,5-Bis(trifluoromethyl)phenyl]acetic Acid; 2-[2,5-Bis(trifluoromethyl)phenyl]acetic Acid; α-[2,5-Bis(trifluoromethyl)phenyl]acetic Acid; 2,5-Bis(trifluoromethyl)benzeneacetic Acid; (2,5-Bis(trifluoromethyl)phenyl)acetic Acid
EINECS	Contact for details

Quality Control

Every batch of 2,5-Bis(Trifluoromethyl)Phenylacetic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended long-term storage at controlled room temperature (15-25°C).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.