Description

Simocyclinone D8 is a deuterated analog of the natural product simocyclinone, a potent antibiotic and DNA gyrase inhibitor. This stable isotope-labeled compound is essential for advanced pharmacokinetic, metabolic, and proteomic research, providing critical internal standards for mass spectrometry. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug discovery and mechanistic studies of novel antibacterial agents.

Application

• Internal standard for the quantitative LC-MS/MS analysis of simocyclinone in biological matrices (plasma, serum, tissue).
• Metabolite identification and drug metabolism studies (DMPK) in preclinical and clinical research.
• Proteomics research to study the interaction between DNA gyrase and inhibitor compounds.
• Stable Isotope Dilution Assay (SIDA) for accurate quantification in complex samples.
• Biochemical pathway tracing and mechanism of action (MOA) studies for novel antibiotics.
• Quality control and method development in analytical laboratories for antibiotic research.

Basic Information

Product Name	Simocyclinone D8
CAS No.	301845-97-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Simocyclinone D8; Deuterated Simocyclinone D8; Simocyclinone-d8; [D8]-Simocyclinone; 301845-97-6; Stable isotope-labeled simocyclinone; DNA gyrase inhibitor D8; Antibiotic research standard D8
EINECS	Contact for details

Quality Control

Our Simocyclinone D8 is produced under strict quality-controlled conditions to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity (by MS), and other critical parameters. We adhere to relevant standards for research chemicals, ensuring batch-to-batch consistency and reliability for your critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥95%
Isotopic Purity (MS)	≥98 atom % D
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.