Description

tert-Butyl-(2-Amino-1-Hydroxyethyl)Piperidine-1-Carboxylate is a high-purity, protected amino alcohol derivative featuring a piperidine scaffold, serving as a critical chiral building block in advanced organic synthesis. Its value lies in its bifunctional nature, offering both a protected amine and a hydroxyl group for selective modification, which is essential for constructing complex molecular architectures with high stereochemical control. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs), novel drug candidates, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, particularly those targeting the central nervous system (CNS).
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where specific stereochemistry is required for biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, such as hydrogenation or cross-coupling reactions.
• Peptidomimetic Research: The piperidine and amino alcohol motifs make it valuable for constructing non-peptide scaffolds that mimic peptide structures in medicinal chemistry.
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring high-purity, specialized intermediates.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and the study of new reaction pathways.

Basic Information

Product Name	tert-Butyl-(2-Amino-1-Hydroxyethyl)Piperidine-1-Carboxylate
CAS No.	301221-57-8
Molecular Formula	C12H24N2O3
Molecular Weight	244.33 g/mol
Synonyms	1-Boc-2-(2-Amino-1-hydroxyethyl)piperidine; 1-(tert-Butoxycarbonyl)-2-(2-amino-1-hydroxyethyl)piperidine; 2-(1-Boc-2-piperidinyl)-2-aminoethanol; tert-Butyl 2-(2-amino-1-hydroxyethyl)piperidine-1-carboxylate; N-Boc-2-(2-amino-1-hydroxyethyl)piperidine; 2-Amino-1-(1-Boc-2-piperidinyl)ethanol; (2-Amino-1-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester; 1,1-Dimethylethyl 2-[(2-amino-1-hydroxyethyl)]-1-piperidinecarboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl-(2-Amino-1-Hydroxyethyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.